Immunity vs. metabolism in the human gut, journal club paper for next week.

On Thursday Dec 1 at 3:30pm in HSC 3N50, Jennifer Lau a graduate student in the Farncombe Family Digestive Health Research Center will present a systems biology paper on the interactions between the immune system, the intestinal epithelium and the microbiota within the gut. Shulzhenko et al. found that an increased immune response by intestinal epithelial cells (in the presence of the microbiota) lead to lipid malabsorption. These genetic networks were previously predicted, through expression analysis, to be inversely connected. This paper and many others (including previous journal club papers and references of interest) can now be accessed on the public human microbiome journal club Mendeley library. Please let us know what you think of the library and feel free to add papers and comments yourselves.

Shulzhenko, Natalia, Andrey Morgun, William Hsiao, Michele Battle, Michael Yao, Oksana Gavrilova, Marlene Orandle, et al. 2011. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nature Medicine, no. November: 1-10.


About Jennifer Stearns

Farncombe Family Chair in Microbial Ecology and Bioinformatics and Assistant Professor at McMaster University
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