Going beyond 16S rRNA gene sequencing to examine the functionality of the gut microbiome.

As the technology advances, so does our ability to probe and profile human microbiomes. Next week, I will lead a discussion of the recent paper entitled Functional Dynamics of the Gut Microbiome in Elderly People during Probiotic Consumption.” by Emiley Eloe-Fadrosh et al. This paper combines together many aspects that we’re interested in here at McMaster, including the inclusion of techniques beyond 16S rRNA gene sequencing to gain a more complete understanding of how the elderly gut community is affected by the popular probiotic, Lactobacillus rhamnosus GG (LGG).

During our journal club Friday, May 1st at 3:30pm, Westend Pub I hope to discuss:
(a) the combined use of 16S rRNA gene sequencing and RNAseq
(b) their conclusions regarding the effect of LGG on the gut microbiota
(c) on the more philosophical: discuss their use of data visualizations, and how we can apply their methods to our own datasets

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One Response to Going beyond 16S rRNA gene sequencing to examine the functionality of the gut microbiome.

  1. Dawn Bowdish says:

    This sounds like a really amazing paper, please post a synopsis for those of us who can’t attend.
    Also, The Labarge Optimal Aging Portal (http://www.mcmasteroptimalaging.org/) is looking for someone to write a blog post summarizing the data whether probiotic ingestion is beneficial for the elderly. Maybe one of your members would be interested?

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