Does dysbiosis drive intestinal inflammation or is dysbiosis resulted from inflammation in IBD?

This Friday the 13th at 3:30pm we continue journal club to discuss: Lewis et al, 2015. Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease.

Dysbiosis, a term that is often misused and over simplified as a reduction in diversity and altered bacterial composition, will be the highlight of our discussion this week. It is well documented that patients with Inflammatory Bowel Disease (IBD) have an altered microbial composition however, is this altered composition a result of inflammation or does it drive inflammation? This paper claims that dysbiosis is reduced when inflammation is reduced. Moreover, inflammation, antibiotic exposure, and diet independently influence specific taxa meaning the response of the gut microbiome depends on the environmental stressor.

Please join us for a great discussion at West End Pub @ 3:30pm!

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