Author Archives: thessyed

Get That Weak Staph Outta Here!

Certain skin commensal bacteria protect individuals against Staphylococcus aureus colonization We’re all covered in skin (hopefully) and our skin is covered with microbes. For the most part, this skin microbiome coexists with us and remains stable, despite our constant contact with other people and our environment. … Continue reading

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Introducing ANCOM a new (hopefully better) tool for microbiome analysis

The most frequently asked question in current analyses of different microbiomes is what organism(s) differentiates these two groups. As microbiologist and aspiring bioinformaticians we are all aware that due to the complex community structures of microbiomes, and the resulting complex … Continue reading

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Follow-up: What is the most appropriate method for associating microbiome data with health and disease?

At this month’s journal club, James, an undergraduate student in Jane Foster’s laboratory at McMaster University, led the discussion on how we can better associate microbiome data with clinical data on health and disease. Beginning with a brief introduction to PERMANOVA … Continue reading

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Why do people have such different microbiomes from one another?

Discussing a computational approach to answering what controls inter-individual variability in the human microbiome. Modulating human microbial communities continues to be an area of intense academic and entrepreneurial interest because of the role of the human microbiome in determining health and … Continue reading

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Oligotyping to Achieve Increased Taxonomic Resolution of the Oral Microbiome

The development of novel bioinformatics tools has allowed for researchers to glean increasing amounts of information from next generation sequencing of 16S rRNA gene data. Current methods of sequence analysis have been limited to taxonomic identity up to genera or … Continue reading

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Summing up: Exploration of the Virome in Inflammatory Bowel Disease by Norman et al.

Last week we drew our attention to the virome as discussed in “Disease-specific alterations in the enteric virome in inflammatory bowel disease” (Norman et. al). Continuing on the thread of ‘other’ components of the microbiome from our discussion last month … Continue reading

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