Tag Archives: microbiome

Why do people have such different microbiomes from one another?

Discussing a computational approach to answering what controls inter-individual variability in the human microbiome. Modulating human microbial communities continues to be an area of intense academic and entrepreneurial interest because of the role of the human microbiome in determining health and … Continue reading

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Citizen Science and the Microbiome: uBiome studies women’s health

Everyone that reads this blog has some stake in the human microbiome game, so I’m assuming that you would all be interested in exploring your own personal microbiomes! If you haven’t heard of them by now, uBiome is a company started … Continue reading

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Oligotyping to Achieve Increased Taxonomic Resolution of the Oral Microbiome

The development of novel bioinformatics tools has allowed for researchers to glean increasing amounts of information from next generation sequencing of 16S rRNA gene data. Current methods of sequence analysis have been limited to taxonomic identity up to genera or … Continue reading

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Summing up: Exploration of the Virome in Inflammatory Bowel Disease by Norman et al.

Last week we drew our attention to the virome as discussed in “Disease-specific alterations in the enteric virome in inflammatory bowel disease” (Norman et. al). Continuing on the thread of ‘other’ components of the microbiome from our discussion last month … Continue reading

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“Disease-specific alterations in the enteric virome in inflammatory bowel disease” [Norman et al, 2015]

Is IBD going viral? Pursuant to last month’s journal club discussion on the importance of examining the fungal mycobiome, a closer look at the intestinal virome seemed like the logical next step. Eukaryotic viruses have the ability to interact with IBD risk … Continue reading

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Summing up: Bassis et al.’s take on the influence of the URT on other human-associated biogeographies.

Last week, Pat led us in the examination of a new paper from the Huffnagle group at the University of Michigan. This was the first meeting of McMaster’s HMBJC in a few months which meant a very lively discussion since … Continue reading

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Next week’s journal club papers on the lung microbiome

Does immunodeficiency associated with HIV infection associate with an altered microbiota in the lungs? In a recent issue of the American Journal of Respiratory and Critical Care Medicine Lozupone et, al. show that it does, by reporting that 13% of HIV-positive subjects have … Continue reading

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Bacteriophage at mucosal sites help keep bacteria at bay

Scientists recently described a new form of symbiosis at our mucosal sites with an unassuming partner: bacteriophage. In a paper published in PNAS, Jeremy Barr and colleagues noticed that phage are enriched at mucosal surfaces compared to surrounding surfaces and … Continue reading

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Sequencing genomes from metagenomic samples

Next week we’re going to switch gears a bit to examine a brand new publication concerning the ability to sequence genomes of low-abundant organisms from large metagenomic samples.  We’ll give a general overview of the methods used, examine the results, … Continue reading

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The human microbiome getting press

The human microbiome and microbiome research in general has been getting some attention in the news lately, so I thought that I’d point you to a couple of interesting podcasts. The first one features our very own Mike Surette in … Continue reading

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